Article
The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence.
Translational psychiatry - 16 Jun 2015
Suchankova P, Yan J, Schwandt M L, Stangl B L, Caparelli E C, Momenan R, Jerlhag E, Engel J A, Hodgkinson C A, Egli M, Lopez M F, Becker H C, Goldman D, Heilig M, Ramchandani V A, Leggio L
Abstract excerpt
The hormone glucagon-like peptide-1 (GLP-1) regulates appetite and food intake. GLP-1 receptor (GLP-1R) activation also attenuates the reinforcing properties of alcohol in rodents. The present translational study is based on four human genetic association studies and one preclinical study providing data that support the hypothesis that GLP-1R may have a role in the pathophysiology of alcohol use disorder (AUD)....
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