Article
Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients.
Leukemia & lymphoma - 1 Jan 2016
Masamoto Izumi, Yoshimitsu Makoto, Kuroki Ayako, Horai Sawako, Ezinne Chibueze Chioma, Kozako Tomohiro, Hachiman Miho, Kamada Yuhei, Baba Masanori, Arima Naomichi
Abstract excerpt
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL). Miscellaneous host immune surveillance systems control T-cell growth/leukemogenesis during HTLV-1 infection. We characterized CD70 and CD27 expression on lymphocytes of HTLV-1 carriers and patients with ATL (study approved by the local Medical Ethical Committee). High CD70 expression was observed on CD4 +...
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