Article
Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis.
Neuroscience letters - 21 Jun 1996
Nakano R, Inuzuka T, Kikugawa K, Takahashi H, Sakimura K, Fujii J, Taniguchi N, Tsuji S
Abstract excerpt
In about 20-25% of cases of familial amyotrophic lateral sclerosis (FALS) patients have mutations in the Cu/Zn superoxide dismutase (SOD1) gene. The mechanism through which the mutations in the SOD1 gene cause ALS still remain unknown. We performed pulse-chase experiments using a system for the transient expression of human SOD1 in COS7 cells to examine whether the Ala4Thr mutation, which we previously reported,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.