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Article

Protein kinetics of superoxide dismutase‐1 in familial and sporadic amyotrophic lateral sclerosis

29 Apr 2023

Abstract excerpt

OBJECTIVE: Accumulation of misfolded superoxide dismutase-1 (SOD1) is a pathological hallmark of SOD1-related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understanding in vivo protein kinetics may clarify how SOD1 influences neurodegeneration and inform optimal dosing for therapies that lower SOD1 transcripts. METHODS: We employed stable...

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PMID: 37119480
DOI: 10.1002/acn3.51784

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