Article
Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients.
Inflammation - 1 Dec 2015
Zhu Wei, Li Xiu, Fang Shaohong, Zhang Xiaoli, Wang Ying, Zhang Tongshuai, Li Zhaoying, Xu Yanwen, Qu Siying, Liu Chuanliang, Gao Fei, Pan Haile, Wang Guangyou, Li Hulun, Sun Bo
Abstract excerpt
We used samples from rheumatoid arthritis (RA) patients to examine whether Anti-citrullinated protein antibodies (ACPAs) alter macrophage subset distribution and promote RA development. Macrophage subset distributions and interferon regulatory factor 4 (IRF4) and IRF5 expressions were analyzed. ACPAs were purified by affinity column. After RA and osteoarthritis (OA) patients' macrophages were cocultured with...
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