Article
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.
Rheumatology (Oxford, England) - 1 Oct 2015
Weitoft Tomas, Larsson Anders, Manivel Vivek A, Lysholm Jörgen, Knight Ann, Rönnelid Johan
Abstract excerpt
OBJECTIVES: Cathepsin S and cathepsin L are endosomal proteolytic enzymes involved in the degradation of extracellular matrixes, angiogenesis and antigen presentation. Cathepsins could thus play several roles in the disease process of RA. The aim of this study was to examine differences in cathepsin S and cathepsin L levels in serum and SF of RA patients with and without ACPA and RF. METHODS: In this study 121...
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