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Article

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.

Oncotarget - 30 Jul 2015

Mandriota Stefano J, Valentijn Linda J, Lesne Laurence, Betts David R, Marino Denis, Boudal-Khoshbeen Mary, London Wendy B, Rougemont Anne-Laure, Attiyeh Edward F, Maris John M, Hogarty Michael D, Koster Jan, Molenaar Jan J, Versteeg Rogier, Ansari Marc, Gumy-Pause Fabienne

Abstract excerpt

Neuroblastoma, a childhood cancer with highly heterogeneous biology and clinical behavior, is characterized by genomic aberrations including amplification of MYCN. Hemizygous deletion of chromosome 11q is a well-established, independent marker of poor prognosis. While 11q22-q23 is the most frequently deleted region, the neuroblastoma tumor suppressor in this region remains to be identified. Chromosome bands...

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Source

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Identifiers

PMID: 26053094
DOI: 10.18632/oncotarget.4061
PMCID: PMC4621910

Genes

ATM
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.PMID 26053094Read ↗

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