Article
Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice.
The Journal of veterinary medical science - 1 Nov 2015
Hirose Takuya, Ogura Takayuki, Tanaka Keisuke, Minaguchi Jun, Yamauchi Takeshi, Fukada Toshiyuki, Koyama Yoh-ichi, Takehana Kazushige
Abstract excerpt
Ehlers-Danlos syndrome (EDS) is a group of disorders caused by abnormalities that are identified in the extracellular matrix. Transforming growth factor-β1 (TGF-β1) plays a crucial role in formation of the extracellular matrix. It has been reported that the loss of function of zinc transporter ZRT/IRT-like protein 13 (ZIP13) causes the spondylocheiro dysplastic form of EDS (SCD-EDS: OMIM 612350), in which...
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