Article
Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2012
Jeong Jeeyon, Walker Joel M, Wang Fudi, Park J Genevieve, Palmer Amy E, Giunta Cecilia, Rohrbach Marianne, Steinmann Beat, Eide David J
Abstract excerpt
Zinc is essential but potentially toxic, so intracellular zinc levels are tightly controlled. A key strategy used by many organisms to buffer cytosolic zinc is to store it within vesicles and organelles.It is yet unknown whether vesicular or organellar sites perform this function in mammals. Human ZIP13, a member of the Zrt/Irt-like protein (ZIP) metal transporter family, might provide an answer to this question....
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