Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses.

Molecular pharmacology - 1 Aug 2015

Oh Jin-Gyo, Chin Young-Won, Kim Sung-Jo, Choi Jong Min, Kim Sang Kyum, Kang Hee Eun, Heo Tae-Hwe

Abstract excerpt

Although ingenol 3,20-dibenzoate (IDB) is known as a selective novel protein kinase C (PKC) agonist, its biologic actions and underlying mechanisms remain incompletely understood. In this study, we identified IDB as a proliferative agent for an erythropoietin (EPO)-dependent cell line, UT-7/EPO, through the screening of a natural compound library. To clarify the underlying mechanism of IDB's EPO-like activities,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diterpenes

Share to Dose-Response Relationship, Drug

Share to Drug Synergism

Share to Erythropoietin

Share to Protein Kinase C

Share to Receptors, Erythropoietin

Source

Identifiers

PMID: 26048958
DOI: 10.1124/mol.114.097436

Genes

EPO
EPOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses.PMID 26048958Read ↗

Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and BiologySemantic proximity Read ↗

Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and DogsSemantic proximity Read ↗

Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation.Semantic proximity Read ↗

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of BimSemantic proximity Read ↗

Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humansSemantic proximity Read ↗

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.Semantic proximity Read ↗

Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study.Semantic proximity Read ↗

Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells.Semantic proximity Read ↗

Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.