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Article

Comparative genomic analysis of Brucella abortus vaccine strain 104M reveals a set of candidate genes associated with its virulence attenuation.

Virulence - 1 Jan 2015

Yu Dong, Hui Yiming, Zai Xiaodong, Xu Junjie, Liang Long, Wang Bingxiang, Yue Junjie, Li Shanhu

Abstract excerpt

The Brucella abortus strain 104M, a spontaneously attenuated strain, has been used as a vaccine strain in humans against brucellosis for 6 decades in China. Despite many studies, the molecular mechanisms that cause the attenuation are still unclear. Here, we determined the whole-genome sequence of 104M and conducted a comprehensive comparative analysis against the whole genome sequences of the virulent strain,...

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Identifiers

PMID: 26039674
DOI: 10.1080/21505594.2015.1038015
PMCID: PMC4826108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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