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Article

Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells.

Investigative ophthalmology & visual science - 1 May 2015

Okumura Naoki, Kakutani Kazuya, Numata Ryohei, Nakahara Makiko, Schlötzer-Schrehardt Ursula, Kruse Friedrich, Kinoshita Shigeru, Koizumi Noriko

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the usefulness of laminin isoforms as substrates for culturing human corneal endothelial cells (HCECs) for clinical application of tissue engineering therapy. METHODS: Expression of specific laminin chains in human corneal endothelium and Descemet's membrane was analyzed at the mRNA and protein levels. The effect of laminin-511 and -521 on cell adhesion and...

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Identifiers

PMID: 26024079
DOI: 10.1167/iovs.14-15163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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