Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets

26 May 2015

Abstract excerpt

The acquisition of stemness is a hallmark of aggressive human hepatocellular carcinoma (hHCC). The stem cell marker OCT4 is frequently expressed in HCCs, and its expression correlates with those of putative cancer stem cell (CSC) markers and CSC properties. Here, we describe a novel mechanism of CSC maintenance by SRY through OCT4. We previously reported that Sry is involved in tumor malignancy in rodent HCCs....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to FOXO transcription factor regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26013162
DOI: 10.1002/stem.2059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy TargetsPMID 26013162Read ↗

The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell SignalingSemantic proximity Read ↗

Sox9 regulates self‐renewal and tumorigenicity by promoting symmetrical cell division of cancer stem cells in hepatocellular carcinomaSemantic proximity Read ↗

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.Semantic proximity Read ↗

Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathwaysSemantic proximity Read ↗

Cancer Stem Cells and Competing Endogenous RNAsSemantic proximity Read ↗

Autophagy regulates the cancer stem cell phenotype of head and neck squamous cell carcinoma through the noncanonical FOXO3/SOX2 axis.Semantic proximity Read ↗

SOX2 Maintains the Stemness of Retinoblastoma Stem-like Cells Through Hippo/YAP Signaling PathwaySemantic proximity Read ↗

Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signalingSemantic proximity Read ↗

Long Noncoding RNA ROR Regulates Proliferation, Invasion, and Stemness of Gastric Cancer Stem CellSemantic proximity Read ↗

BORIS up-regulates OCT4 via histone methylation to promote cancer stem cell-like properties in human liver cancer cells.Semantic proximity Read ↗

Cancer stem/progenitor cells are highly enriched in CD133<sup>+</sup>CD44<sup>+</sup> population in hepatocellular carcinomaSemantic proximity Read ↗

Roles Played by YY1 in Embryonic, Adult and Cancer Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.