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Article

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms

25 May 2015

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are characterized by the clonal expansion of one or more myeloid cell lineage. In most cases, proliferation of the malignant clone is ascribed to defined genetic alterations. MPNs are also associated with aberrant expression and activity of multiple cytokines; however, the mechanisms by which these cytokines contribute to disease pathogenesis are poorly understood. Here, we...

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PMID: 26011644
DOI: 10.1172/jci77347

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