BRCC3 mutations in myeloid neoplasms.

doi:10.3324/haematol.2014.111989

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Article

BRCC3 mutations in myeloid neoplasms.

Haematologica - 1 Aug 2015

Huang Dayong, Nagata Yasunobu, Grossmann Vera, Radivoyevitch Tomas, Okuno Yusuke, Nagae Genta, Hosono Naoko, Schnittger Susanne, Sanada Masashi, Przychodzen Bartlomiej, Kon Ayana, Polprasert Chantana, Shen Wenyi, Clemente Michael J, Phillips James G, Alpermann Tamara, Yoshida Kenichi, Nadarajah Niroshan, Sekeres Mikkael A, Oakley Kevin, Nguyen Nhu, Shiraishi Yuichi, Shiozawa Yusuke, Chiba Kenichi, Tanaka Hiroko, Koeffler H Phillip, Klein Hans-Ulrich, Dugas Martin, Aburatani Hiroyuki, Miyano Satoru, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten, Du Yang, Ogawa Seishi, Makishima Hideki

Abstract excerpt

Next generation sequencing technologies have provided insights into the molecular heterogeneity of various myeloid neoplasms, revealing previously unknown somatic genetic events. In our cohort of 1444 cases analyzed by next generation sequencing, somatic mutations in the gene BRCA1-BRCA2-containing complex 3 (BRCC3) were identified in 28 cases (1.9%). BRCC3 is a member of the JAMM/MPN+ family of zinc...

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Identifiers

PMID: 26001790
DOI: 10.3324/haematol.2014.111989
PMCID: PMC5004421

Genes

BRCC3
BRCA1
BRCA2

Provenance

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