Article
Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example.
Scientific reports - 21 May 2015
Klonowska Katarzyna, Ratajska Magdalena, Czubak Karol, Kuzniacka Alina, Brozek Izabela, Koczkowska Magdalena, Sniadecki Marcin, Debniak Jaroslaw, Wydra Dariusz, Balut Magdalena, Stukan Maciej, Zmienko Agnieszka, Nowakowska Beata, Irminger-Finger Irmgard, Limon Janusz, Kozlowski Piotr
Abstract excerpt
Only approximately 50% of all familial breast cancers can be explained by known genetic factors, including mutations in BRCA1 and BRCA2. One of the most extensively studied candidates for breast and/or ovarian cancer susceptibility is BARD1. Although it was suggested that large mutations may contribute substantially to the deleterious variants of BARD1, no systematic study of the large mutations in BARD1 has been...
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