Article
A network flow-based method to predict anticancer drug sensitivity.
PloS one - 1 Jan 2015
Qin Yufang, Chen Ming, Wang Haiyun, Zheng Xiaoqi
Abstract excerpt
Predicting anticancer drug sensitivity can enhance the ability to individualize patient treatment, thus making development of cancer therapies more effective and safe. In this paper, we present a new network flow-based method, which utilizes the topological structure of pathways, for predicting anticancer drug sensitivities. Mutations and copy number alterations of cancer-related genes are assumed to change the...
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