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Transfer learning with multiomics integration and deep neural networks reveals drug resistance mechanisms in cancer

27 Nov 2025

Abstract excerpt

Drug resistance remains one of the primary challenges in effective cancer therapy. In this study, we employed a deep neural network (DNN)-based transfer learning (TL) approach to predict drug response and uncover drug resistance mechanisms. We integrated gene expression, somatic mutation, and copy number aberration (CNA) data with drug response profiles using multi-omics integration (MI). We used the Genomics of...

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PMID: 41309738
DOI: 10.1038/s41598-025-23435-8

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