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ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy.

Cancer chemotherapy and pharmacology - 1 Aug 2020

Nomura Hisanaga, Tsuji Daiki, Demachi Ken, Mochizuki Nobuo, Matsuzawa Haruki, Yano Tomonori, Daiko Hiroyuki, Fujii Satoshi, Kojima Takashi, Itoh Kunihiko, Kawasaki Toshikatsu

Abstract excerpt

PURPOSE: The combination of docetaxel, cisplatin and 5-fluorouracil (DCF) is a newly developed chemotherapy regimen for esophageal cancer. Severe neutropenia is dose-limiting toxicity of docetaxel and it is well known to be frequently occurred during DCF chemotherapy. This study aimed to investigate the relationship between severe neutropenia and genetic polymorphisms in patients treated with preoperative DCF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32748110
DOI: 10.1007/s00280-020-04118-9

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