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Article

Association of IRF8 gene polymorphisms with autoimmune thyroid disease.

European journal of clinical investigation - 1 Jul 2015

Lin Jiunn-Diann, Wang Yuan-Hung, Liu Chia-Hung, Lin Ying-Chin, Lin Jui-An, Lin Yuh-Feng, Tang Kam-Tsun, Cheng Chao-Wen

Abstract excerpt

BACKGROUND: The occurrence of autoimmune thyroid disease (AITD) is known to have a major adverse effect on interferon (INF)-α treatment. The genetic variant of the INF regulatory factor 8 (IRF8), a type 1 INF regulator, is associated with susceptibility to systemic lupus erythematosus and multiple sclerosis. In this study, we investigated possible associations of the IRF8 polymorphisms, rs17445836 and rs2280381,...

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Identifiers

PMID: 25989711
DOI: 10.1111/eci.12463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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