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Article

miR-196a-5p modulates gastric cancer stem cell characteristics by targeting Smad4

19 Apr 2017

Abstract excerpt

Cancer stem cells (CSCs) are undifferentiated cancer cells with a high tumorigenic activity, the ability to undergo self-renewal, and a multilineage differentiation potential. Clinical evidence suggests that CSCs in a tumor mass are the cellular determinants to promote cancer invasion and metastasis. MicroRNAs (miRNAs) have emerged as important modulators of cancer stem cell characteristics. Unveiling the...

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PMID: 28440445
DOI: 10.3892/ijo.2017.3965

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