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Article

Survey and evaluation of mutations in the human KLF1 transcription unit.

Scientific reports - 26 Apr 2018

Gnanapragasam Merlin Nithya, Crispino John D, Ali Abdullah M, Weinberg Rona, Hoffman Ronald, Raza Azra, Bieker James J

Abstract excerpt

Erythroid Krüppel-like Factor (EKLF/KLF1) is an erythroid-enriched transcription factor that plays a global role in all aspects of erythropoiesis, including cell cycle control and differentiation. We queried whether its mutation might play a role in red cell malignancies by genomic sequencing of the KLF1 transcription unit in cell lines, erythroid neoplasms, dysplastic disorders, and leukemia. In addition, we...

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Source

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Identifiers

PMID: 29700354
DOI: 10.1038/s41598-018-24962-3
PMCID: PMC5920080

Genes

KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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