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Development of reverse genetic tools to study Chapare and Machupo viruses

22 Sept 2023

Abstract excerpt

Arenaviruses are highly pathogenic viruses that pose a serious public health threat. Chapare virus (CHAV) and Machupo virus (MACV), two New World arenaviruses, cause hemorrhagic fevers with case fatality rates of up to 45%. Research on therapeutic drug targets and vaccines for these viruses is limited because biosafety level 4 containment is required for handling them. In this study, we developed reverse genetics...

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PMID: 37774602
DOI: 10.1016/j.virol.2023.109888

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