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Article

Structural and functional consequences of succinate dehydrogenase subunit B mutations.

Endocrine-related cancer - 1 Jun 2015

Kim E, Rath E M, Tsang V H M, Duff A P, Robinson B G, Church W B, Benn D E, Dwight T, Clifton-Bligh R J

Abstract excerpt

Mitochondrial dysfunction, due to mutations of the gene encoding succinate dehydrogenase (SDH), has been implicated in the development of adrenal phaeochromocytomas, sympathetic and parasympathetic paragangliomas, renal cell carcinomas, gastrointestinal stromal tumours and more recently pituitary tumours. Underlying mechanisms behind germline SDH subunit B (SDHB) mutations and their associated risk of disease are...

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Source

Identifiers

PMID: 25972245
DOI: 10.1530/ERC-15-0099

Genes

SDHB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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