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Article

Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors.

Oncotarget - 20 Jul 2015

Cai Jinquan, Chen Jing, Zhang Wei, Yang Pei, Zhang Chuanbao, Li Mingyang, Yao Kun, Wang Hongjun, Li Qingbin, Jiang Chuanlu, Jiang Tao

Abstract excerpt

Loss of ATRX leads to epigenetic alterations, including abnormal levels of DNA methylation at repetitive elements such as telomeres in murine cells. We conducted an extensive DNA methylation and mRNA expression profile study on a cohort of 82 patients with astrocytic tumors to study whether ATRX expression was associated with DNA methylation level in astrocytic tumors and in which cellular functions it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25971279
DOI: 10.18632/oncotarget.3906
PMCID: PMC4627238

Genes

ATRX
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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