Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is Bad Luck the Main Cause of Cancer?

8 May 2015

Abstract excerpt

A recent study reports that the log lifetime incidence rate across a selection of 31 cancer types is highly correlated with the log of the estimated tissue-specific lifetime number of stem cell divisions. This observation, which underscores the importance of errors in DNA replication, has been viewed as implying that most cancers arise through unavoidable bad luck, leading to the suggestion that research efforts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Global Cancer Incidence and Screening

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25956173
DOI: 10.1093/jnci/djv125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is Bad Luck the Main Cause of Cancer?PMID 25956173Read ↗

A Critical Examination of the “Bad Luck” Explanation of Cancer RiskSemantic proximity Read ↗

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.Semantic proximity Read ↗

Strategies to Prevent "Bad Luck" in Cancer.Semantic proximity Read ↗

A research note regarding "Variation in cancer risk among tissues can be explained by the number of stem cell divisions"Semantic proximity Read ↗

Of Cancer and Random Mutations.Semantic proximity Read ↗

Cancer risk: Many factors contributeSemantic proximity Read ↗

Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations.Semantic proximity Read ↗

A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of agingSemantic proximity Read ↗

Characterizing causality in cancerSemantic proximity Read ↗

Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates.Semantic proximity Read ↗

The Implications of "Random Chance" in Cancer Genesis: Why Stochastic Can Be a Dirty Word.Semantic proximity Read ↗

The (not so) immortal strand hypothesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.