Article
Association analysis of polymorphisms of the CRHR1 gene with infantile spasms.
Molecular medicine reports - 1 Aug 2015
Yang Guang, Zou Li-Ping, Wang Jing, Shi Xiu-Yu, Yang Xiao-Fan, Wang Bin, Liu Yu-Jie, Sun Yan-Hong, Jia Fei-Yong
Abstract excerpt
While >200 types of etiologies have been shown to be involved in the pathogenesis of infantile spasms, the pathophysiology of infantile spasms remains largely elusive. Pre-natal stress and hypothalamic-pituitary-adrenal axis dysfunction were shown to be involved in the development of infantile spasms. To test the genetic association between the CRHR1 gene, which encodes the corticotrophin-releasing hormone (CRH)...
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