Article
Common ABCB1 polymorphisms associated with susceptibility to infantile spasms in the Chinese Han population.
Genetics and molecular research : GMR - 19 Oct 2011
Dong L, Mao M, Luo R, Tong Y, Yu D
Abstract excerpt
Infantile spasms are a severe epileptic encephalopathy with a variety of etiologies that occur in infancy and early childhood. Subjects with infantile spasms are at a higher risk for evolving into intractable epileptic spasms, tending to be refractory to conventional antiepileptic drugs. Genetic polymorphisms of the P-glycoprotein-encoding gene ABCB1 are suspected to be associated with pharmacoresistance...
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