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Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

23 Aug 2019

Abstract excerpt

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent immortalized erythroblast cell line (BEL-A) support both successful invasion and intracellular development of the malaria parasite Plasmodium falciparum. Using...

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PMID: 31444345
DOI: 10.1038/s41467-019-11790-w

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