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Article

Inborn Errors of Immunity in the NF-κB Pathway.

Pediatrics international : official journal of the Japan Pediatric Society - 1 Jan 2026

Moriya Kunihiko

Abstract excerpt

Inborn errors of immunity (IEIs) affecting the NF-κB pathway impair innate and/or adaptive immune responses and may present with or without developmental abnormalities. In this review, we summarize our recent findings from two studies. Monoallelic variants in the RELA gene that result in haploinsufficiency have been linked to tumor necrosis factor-dependent chronic mucosal ulcers and autoimmune cytopenias....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42261849
DOI: 10.1111/ped.70424

Genes

RELA
TLR7
MYD88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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