Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.

Science (New York, N.Y.) - 10 Feb 2006

Barbera Andrew J, Chodaparambil Jayanth V, Kelley-Clarke Brenna, Joukov Vladimir, Walter Johannes C, Luger Karolin, Kaye Kenneth M

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral
Share to Chromosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human

Share to Chromosomes, Mammalian

Share to Dimerization

Share to Herpesvirus 8, Human

Share to Nucleosomes

Share to Xenopus laevis

Source

Identifiers

PMID: 16469929
DOI: 10.1126/science.1120541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.PMID 16469929Read ↗

Kaposi’s Sarcoma-Associated Herpesvirus LANA Hitches a Ride on the ChromosomeSemantic proximity Read ↗

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNASemantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral PersistenceSemantic proximity Read ↗

Site-Specific Association with Host and Viral Chromatin by Kaposi's Sarcoma-Associated Herpesvirus LANA and Its Reversal during Lytic ReactivationSemantic proximity Read ↗

Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANASemantic proximity Read ↗

KSHV LANA—The Master Regulator of KSHV LatencySemantic proximity Read ↗

Non-canonical histone H3.3 and its chaperones HIRA and DAXX participate in the regulation of KSHV latencySemantic proximity Read ↗

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.Semantic proximity Read ↗

Kaposi’s Sarcoma Herpesvirus Genome PersistenceSemantic proximity Read ↗

Human Cytomegalovirus Major Immediate Early 1 Protein Targets Host Chromosomes by Docking to the Acidic Pocket on the Nucleosome SurfaceSemantic proximity Read ↗

LANA Binds to Multiple Active Viral and Cellular Promoters and Associates with the H3K4Methyltransferase hSET1 ComplexSemantic proximity Read ↗

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.