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Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome

13 Jun 2013

Abstract excerpt

Recent studies have shown that more than 80% of bone marrow (BM) samples from patients with myelodysplastic syndrome (MDS) harbor somatic mutations and/or genomic aberrations, which are of diagnostic and prognostic importance. We investigated the potential use of peripheral blood (PB) and serum to identify and monitor BM-derived genetic markers using high-resolution single nucleotide polymorphism array (SNP-A)...

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PMID: 23760614
DOI: 10.1182/blood-2012-12-471847

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