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Article

Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice.

International journal of molecular sciences - 30 Apr 2015

Wang Ruey-Sheng, Chang Heng-Yu, Kao Shu-Huei, Kao Cheng-Heng, Wu Yi-Chen, Yeh Shuyuan, Tzeng Chii-Reuy, Chang Chawnshang

Abstract excerpt

In the ovary, the paracrine interactions between the oocyte and surrounded granulosa cells are critical for optimal oocyte quality and embryonic development. Mice lacking the androgen receptor (AR⁻/⁻) were noted to have reduced fertility with abnormal ovarian function that might involve the promotion of preantral follicle growth and prevention of follicular atresia. However, the detailed mechanism of how AR in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Potential, Mitochondrial

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Source

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Identifiers

PMID: 25941928
DOI: 10.3390/ijms16059831
PMCID: PMC4463620

Genes

NRF1
TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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