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Article

Subfertility and defective folliculogenesis in female mice lacking androgen receptor.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2004

Hu Yueh-Chiang, Wang Peng-Hui, Yeh Shuyuan, Wang Ruey-Sheng, Xie Chao, Xu Qingquan, Zhou Xinchang, Chao Hsiang-Tai, Tsai Meng-Yin, Chang Chawnshang

Abstract excerpt

The roles of the androgen receptor (AR) in female fertility and ovarian function remain largely unknown. Here we report on the generation of female mice lacking AR (AR(-/-)) and the resulting influences on the reproductive system. Female AR(-/-) mice appear normal but show longer estrous cycles and reduced fertility. The ovaries from sexually mature AR(-/-) females exhibited a marked reduction in the number of...

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Source

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Identifiers

PMID: 15277682
DOI: 10.1073/pnas.0404372101
PMCID: PMC509185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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