Article
The E3 ligase ube3a is required for learning in Drosophila melanogaster.
Biochemical and biophysical research communications - 19 Jun 2015
Chakraborty Moumita, Paul Blesson K, Nayak Tanmoyita, Das Aniruddha, Jana Nihar R, Bhutani Supriya
Abstract excerpt
Angelman syndrome and autism are neurodevelopmental disorders linked to mutations and duplications of an E3 ligase called ube3a respectively. Since cognitive deficits and learning disabilities are hallmark symptoms of both these disorders, we investigated a role for dube3a in the learning ability of flies using the aversive phototaxis suppression assay. We show that down and up-regulation of dube3a are both...
Topics
- Animals
- Animals, Genetically Modified
- Brain
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Immunoblotting
- Larva
- Learning
- Memory
- Motor Activity