Article
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.
European journal of human genetics : EJHG - 1 Feb 2016
Coleman Ciara, Quinn Emma M, Ryan Anthony W, Conroy Judith, Trimble Valerie, Mahmud Nasir, Kennedy Nicholas, Corvin Aiden P, Morris Derek W, Donohoe Gary, O'Morain Colm, MacMathuna Padraic, Byrnes Valerie, Kiat Clifford, Trynka Gosia, Wijmenga Cisca, Kelleher Dermot, Ennis Sean, Anney Richard J L, McManus Ross
Abstract excerpt
Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established coeliac susceptibility genes and are required for the presentation of gliadin to the immune system resulting in damage to the intestinal mucosa. In the largest association analysis of CD to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.