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Article

Genetic ancestry as an effect modifier of naltrexone in smoking cessation among African Americans: an analysis of a randomized controlled trial.

Pharmacogenetics and genomics - 1 Jun 2015

Bress Adam, Kittles Rick, Wing Coady, Hooker Stanley E, King Andrea

Abstract excerpt

OBJECTIVES: To determine whether there were differential quit rates between African Americans (AA) and European Americans with the experimental treatment naltrexone, and examine the role of genetic ancestry on these outcomes among AAs. METHODS: Data from a previous randomized trial of 315 smokers to naltrexone versus placebo were reanalyzed using West African (WA) genetic ancestry to define subpopulations....

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Identifiers

PMID: 25918964
DOI: 10.1097/FPC.0000000000000138
PMCID: PMC4413945

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