Genetic ancestry in lung-function predictions.

doi:10.1056/NEJMoa0907897

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Article

Genetic ancestry in lung-function predictions.

The New England journal of medicine - 22 Jul 2010

Kumar Rajesh, Seibold Max A, Aldrich Melinda C, Williams L Keoki, Reiner Alex P, Colangelo Laura, Galanter Joshua, Gignoux Christopher, Hu Donglei, Sen Saunak, Choudhry Shweta, Peterson Edward L, Rodriguez-Santana Jose, Rodriguez-Cintron William, Nalls Michael A, Leak Tennille S, O'Meara Ellen, Meibohm Bernd, Kritchevsky Stephen B, Li Rongling, Harris Tamara B, Nickerson Deborah A, Fornage Myriam, Enright Paul, Ziv Elad, Smith Lewis J, Liu Kiang, Burchard Esteban González

Abstract excerpt

BACKGROUND: Self-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lung function and whether its use could improve predictions of lung function among persons who identified themselves as African American. METHODS: We assessed...

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PMID: 20647190
DOI: 10.1056/NEJMoa0907897
PMCID: PMC2922981

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