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Article

An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.

Pain - 1 Oct 2015

Livshits Gregory, Macgregor Alexander J, Gieger Christian, Malkin Ida, Moayyeri Alireza, Grallert Harald, Emeny Rebecca T, Spector Tim, Kastenmüller Gabi, Williams Frances M K

Abstract excerpt

Chronic widespread musculoskeletal pain (CWP) is common, having a population prevalence of 10%. This study aimed to define the biological basis of the CWP/body mass association by using a systems biology approach. Adult female twins (n = 2444) from the TwinsUK registry who had extensive clinical, anthropometric, and "omic" data were included. Nontargeted metabolomics screening including 324 metabolites was...

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Identifiers

PMID: 25915148
DOI: 10.1097/j.pain.0000000000000200
PMCID: PMC4770329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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