Article
The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene.
International journal of cancer - 15 Dec 2009
Daniel-Carmi Vered, Makovitzki-Avraham Efrat, Reuven Eliran-Moshe, Goldstein Ido, Zilkha Noga, Rotter Varda, Tzehoval Esther, Eisenbach Lea
Abstract excerpt
The human 1-8 interferon inducible gene family consists of at least 3 functional genes; 9-27, 1-8D and 1-8U, which are all linked on an 18-kb fragment of chromosome 11 and are highly homologous. It has recently been shown by us and others that the 1-8D gene is overexpressed in colon carcinoma. Here, we show, by sequence comparison of the 1-8D in pairs of tumor/normal colon tissues, the existence of 6 different...
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