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Article

Oligodendrocyte development and CNS myelination are unaffected in a mouse model of severe spinal muscular atrophy.

Human molecular genetics - 15 Jan 2017

O'Meara Ryan W, Cummings Sarah E, De Repentigny Yves, McFall Emily, Michalski John-Paul, Deguise Marc-Olivier, Gibeault Sabrina, Kothary Rashmi

Abstract excerpt

The childhood neurodegenerative disease spinal muscular atrophy (SMA) is caused by loss-of-function mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene resulting in insufficient levels of survival motor neuron (SMN) protein. Classically considered a motor neuron disease, increasing evidence now supports SMA as a multi-system disorder with phenotypes discovered in cortical neuron, astrocyte, and...

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Share to Muscular Atrophy, Spinal
Share to Nerve Fibers, Myelinated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28069797
DOI: 10.1093/hmg/ddw385

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Oligodendrocyte development and CNS myelination are unaffected in a mouse model of severe spinal muscular atrophy.PMID 28069797Read ↗

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Therapeutic strategies for spinal muscular atrophy: SMN and beyondSemantic proximity Read ↗

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesisSemantic proximity Read ↗

Spinal muscular atrophy: from tissue specificity to therapeutic strategiesSemantic proximity Read ↗

The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy.Semantic proximity Read ↗

Neuronal-Specific Roles of the Survival Motor Neuron ProteinSemantic proximity Read ↗

Smn deficiency causes neuritogenesis and neurogenesis defects in the retinal neurons of a mouse model of spinal muscular atrophySemantic proximity Read ↗

Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy.Semantic proximity Read ↗

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