Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway.

PloS one - 1 Jan 2015

Dong Ying, Gao Guirong, Fan Hongyan, Li Shengxian, Li Xuhang, Liu Wei

Abstract excerpt

Activation of Liver X receptors (LXRs), key transcriptional regulators of glucose metabolism, normalizes glycemia and improves insulin sensitivity in rodent models with insulin resistance. However, the molecular mechanism is unclear. This study is aimed to elucidate the mechanism of LXRs-mediated liver glucose metabolic regulation in vitro and in vivo. Db/db mice were used as an in vivo model of diabetes;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hep G2 Cells
Share to Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism

Share to Liver X Receptors

Share to MAP Kinase Signaling System

Share to Orphan Nuclear Receptors

Share to Proto-Oncogene Proteins c-akt

Share to Sulfonamides

Source

Open in PubMed Open full text

Identifiers

PMID: 25909991
DOI: 10.1371/journal.pone.0124778
PMCID: PMC4409387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway.PMID 25909991Read ↗

α-linolenic Acid Regulates Macrophages NF-κB/NLRP3 Signal Pathway via Binding GPR120 to Inhibit Inflammation in Type 2 DiabetesSemantic proximity Read ↗

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular DiseasesSemantic proximity Read ↗

Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.Semantic proximity Read ↗

Synergistic interaction of ellagic acid with diabetes on hepatic tissue, and the expression profile of insulin like growth factor-1 and Klotho genesSemantic proximity Read ↗

Inhibition of Lipid Accumulation in NAFLD Liver by Extract of Rosa laevigata Fruit Extract through Activation of the PI3K-AKT Signaling PathwaySemantic proximity Read ↗

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.Semantic proximity Read ↗

Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene ProgramsSemantic proximity Read ↗

Glucagon-Like Peptide-1 Receptor Mediates the Improvement of Glycolipid Metabolism Disorder via AKT and AMPK Signaling Pathways in L02 with Insulin ResistanceSemantic proximity Read ↗

Regulation effects of rosemary ( Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD ratsSemantic proximity Read ↗

Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2Semantic proximity Read ↗

Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.Semantic proximity Read ↗

Fenofibrate Alleviates Insulin Resistance and Hepatic Steatosis via Modulation of let-7/ SERCA2b AxisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.