Article
Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression.
PloS one - 1 Jan 2014
Teixeira Ana L, Dias Francisca, Ferreira Marta, Gomes Mónica, Santos Juliana I, Lobo Francisco, Maurício Joaquina, Machado José Carlos, Medeiros Rui
Abstract excerpt
The epidermal growth factor (EGF) is responsible for the activation of intracellular signal transducers that act on cell-cycle progression, cell motility, angiogenesis and inhibition of apoptosis. However, cells can block these effects activating opposite signaling pathways, such as the transforming growth factor beta 1 (TGFβ1) pathway. Thus changes in expression levels of EGF and TGFB1 in renal cells might...
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