Revisiting MHC genes in spondyloarthritis.

doi:10.1007/s11926-015-0516-1

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Article

Revisiting MHC genes in spondyloarthritis.

Current rheumatology reports - 1 Jun 2015

Breban Maxime, Costantino Félicie, André Claudine, Chiocchia Gilles, Garchon Henri-Jean

Abstract excerpt

Spondyloarthritis (SpA) refers to a variety of inflammatory rheumatic disorders with strong heritability. Shared genetic predisposition, as shown by familial aggregation, is largely attributable to the major histocompatibility complex (MHC) locus, which was estimated to account for approximately half of the whole disease heritability. The first predisposing allele identified more than 40 years ago is HLA-B27,...

Topics

Aminopeptidases
Genes, MHC Class I
Genetic Predisposition to Disease
HLA-B27 Antigen
Humans
Major Histocompatibility Complex
Polymorphism, Genetic
Receptors, KIR
Spondylarthritis

Source

Open in PubMed

Identifiers

PMID: 25903667
DOI: 10.1007/s11926-015-0516-1

Genes

ERAP1
ERAP2
NPEPPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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