Article
Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis.
Allergy - 1 Jul 2015
Aktar M K, Kido-Nakahara M, Furue M, Nakahara T
Abstract excerpt
BACKGROUND: Endothelin-1 (ET-1) has been reported to evoke histamine-independent pruritus in mammals. However, its association with pruritus or inflammation of atopic dermatitis (AD) has not been clarified. We sought to investigate the role of ET-1 in the skin inflammation of AD. METHODS: To examine the role of ET-1 in AD, we investigated the expression of ET-1 and IL-25 in the skin of an AD mouse model and...
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