Article
Genome-wide next-generation DNA and RNA sequencing reveals a mutation that perturbs splicing of the phosphatidylinositol glycan anchor biosynthesis class H gene (PIGH) and causes arthrogryposis in Belgian Blue cattle.
BMC genomics - 18 Apr 2015
Sartelet Arnaud, Li Wanbo, Pailhoux Eric, Richard Christophe, Tamma Nico, Karim Latifa, Fasquelle Corinne, Druet Tom, Coppieters Wouter, Georges Michel, Charlier Carole
Abstract excerpt
BACKGROUND: Cattle populations are characterized by regular outburst of genetic defects as a result of the extensive use of elite sires. The causative genes and mutations can nowadays be rapidly identified by means of genome-wide association studies combined with next generation DNA sequencing, p...
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