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Article

Clinical trials in hospitalized heart failure patients: targeting interventions to optimal phenotypic subpopulations.

Heart failure reviews - 1 Jul 2015

Vaduganathan Muthiah, Butler Javed, Roessig Lothar, Fonarow Gregg C, Greene Stephen J, Metra Marco, Cotter Gadi, Kupfer Stuart, Zalewski Andrew, Sato Naoki, Filippatos Gerasimos, Gheorghiade Mihai

Abstract excerpt

With one possible exception, the last decade of clinical trials in hospitalized heart failure (HHF) patients has failed to demonstrate improvement in long-term clinical outcomes. This trend necessitates a need to evaluate optimal drug development strategies and standards of trial conduct. It has...

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PMID: 25894076
DOI: 10.1007/s10741-015-9485-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25894076-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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