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Article

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins.

Microbial cell factories - 16 Apr 2015

Mamat Uwe, Wilke Kathleen, Bramhill David, Schromm Andra Beate, Lindner Buko, Kohl Thomas Andreas, Corchero José Luis, Villaverde Antonio, Schaffer Lana, Head Steven Robert, Souvignier Chad, Meredith Timothy Charles, Woodard Ronald Wesley

Abstract excerpt

BACKGROUND: Lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a potent agonist for Toll-like receptor 4/myeloid differentiation factor 2-mediated pro-inflammatory activity in mammals and, thus, represents the endotoxic...

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Identifiers

PMID: 25890161
DOI: 10.1186/s12934-015-0241-5
PMCID: PMC4404585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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