Article
Published sequences do not support transfer of oseltamivir resistance mutations from avian to human influenza A virus strains.
BMC infectious diseases - 28 Mar 2015
Norberg Peter, Lindh Magnus, Olofsson Sigvard
Abstract excerpt
BACKGROUND: Tamiflu (oseltamivir phosphate ester, OE) is a widely used antiviral active against influenza A virus. Its active metabolite, oseltamivir carboxylate (OC), is chemically stable and secreted into wastewater treatment plants. OC contamination of natural habitats of waterfowl might induce OC resistance in influenza viruses persistently infecting waterfowl, and lead to transfer of OC-resistance from avian...
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