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Article

Oseltamivir Resistance in Influenza A(H6N2) Caused by an R292K Substitution in Neuraminidase Is Not Maintained in Mallards without Drug Pressure.

PloS one - 1 Jan 2015

Gillman Anna, Muradrasoli Shaman, Mårdnäs Andreas, Söderström Hanna, Fedorova Ganna, Löwenthal Max, Wille Michelle, Daggfeldt Annika, Järhult Josef D

Abstract excerpt

BACKGROUND: Wild waterfowl is the natural reservoir of influenza A virus (IAV); hosted viruses are very variable and provide a source for genetic segments which can reassort with poultry or mammalian adapted IAVs to generate novel species crossing viruses. Additionally, wild waterfowl act as a reservoir for highly pathogenic IAVs. Exposure of wild birds to the antiviral drug oseltamivir may occur in the...

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PMID: 26422258
DOI: 10.1371/journal.pone.0139415
PMCID: PMC4589409

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